500 Wound Coverage for Massive Burn Injuries ≥50% TBSA – A Systematic Review and Meta-Analysis

Abstract Introduction Early wound coverage remains one of the most essential variables influencing survival extensively burned patients, especially with a total surface area (TBSA) more than 50%. In patients limited donor sites, techniques such as e.g. Meek micrograft procedure or cultured epidermal allografts have proven to be viable methods. this systematic review (SR) and meta-analysis (MA) we studied outcomes different for in massive burn injuries ≥50% TBSA within last 17 years. Methods According PRISMA guideline medical databases PubMed, Cochrane, Embase, Web Science Medical records were screened 5 languages from 01/2005 until 01/2022 by three reviewers, independently. Inclusion criteria prospective retrospective studies on burns TBSA. Results After two-stage process, 33 identified SR MA. Regions publication Asia (n=15), North America (n=8), Europe (n=7), Australia (n=3). total, 1678 mean age 31.4 ± 14.2 years included. The male female ratio was 2.25 : 1. Mean 66,5 12.2%. consisted micrografts, epithelial autografts and/or allografts. length stay 76.5 32.4 days. Initial graft-take 78,0 15.8%. Grafting did neither substantially differ nor healing rate. Conclusions rates comparable between procedure, combined techniques. Applicability Research Practice Wound expansion up 1:10 potential combination should considered early injury.